These are called breaking changes for a reason - in upgrading to ASP.NET 4, you run the chance of running into any of these things that can break your website. I recently updated my account with DiscountASP and moved this domain to a Windows Server 2008/.NET 4 environment. The next step was to get my TDPE stages in place, which required addressing web.config inheritance issues. Today, I wanted to post about TDPE 2 launching... only to be greeted with the request validation errors. Um... this worked just fine, why am I seeing this now? Oh yeah... I moved servers....
So, if you're moving your BlogEngine blog to a .NET 4 environment fron a .NET 2 environment and have some validateRequest="False" files, make sure that the following setting appears in your web.config:
<httpRuntime requestValidationMode="2.0" />
For this and other breaking changes, see the ASP.NET 4 Breaking Changes whitepaper.